General and Intensive Care Outcomes for Hospitalized Patients With Solid Organ Transplants With COVID-19. (April 2021)

• Record Type: Journal Article
• Authors: Mastroianni, Fiore; Leisman, Daniel E.; Fisler, Grace; Narasimhan, Mangala
• Is Part Of: Journal of intensive care medicine. Volume 36:Number 4(2021)
• Page Start: 494
• Page End: 499
• Publication Date: 2021-04
• Subjects: critical care -- endotracheal intubation -- infections -- respiratory failure; Critical care medicine -- Periodicals; Critical Care -- Periodicals; Soins intensifs -- Périodiques; Soins intensifs; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.02805
• DOI: 10.1177/0885066620965163
• Languages: English
• ISSNs: 0885-0666

Abstract

Purpose: COVID-19 has been associated with a dysregulated inflammatory response. Patients who have received solid-organ transplants are more susceptible to infections in general due to the use of immunosuppressants. We investigated factors associated with mechanical ventilation and outcomes in solid-organ transplant recipients with COVID-19. Materials and Methods: We conducted a retrospective cohort study of all solid-organ transplant recipients admitted with a diagnosis of COVID-19 in our 23-hospital health system over a 1-month period. Descriptive statistics were used to describe hospital course and laboratory results and bivariate comparisons were performed on variables to determine differences. Results: Twenty-two patients with solid-organ transplants and COVID-19 were identified. Eight patients were admitted to the ICU, of which 7 were intubated. Admission values of CRP (p = 0.045) and N/L ratio (p = 0.047) were associated with the need for mechanical ventilation. Seven patients (32%) died during admission, including 86% (n = 6) of patients who received mechanical ventilation. Conclusions: In solid-organ transplant recipients with COVID-19, initial CRP and N/L ratio were associated with need for mechanical ventilation.