Rechallenge of voriconazole successfully tolerated after hepatic toxicity. (2020)

• Record Type: Journal Article
• Authors: Narumoto, O.; Suzuki, J.; Takeda, K.; Tamura, A.; Nagai, H.; Matsui, H.
• Is Part Of: Respiratory medicine case reports. Volume 31(2020)
• Publication Date: 2020
• Subjects: Voriconazole -- Rechallenge -- Liver toxicity -- Desensitization -- Aspergillosis; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2020.101191
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Infections caused by Aspergillus species are often life-threatening. Drugs effective for Aspergillus infection are limited. Voriconazole is one of the most important drugs, however, considerable portion of patients experience liver toxicity and have to stop the drug administration. We frequently experience liver toxicity even though the serum concentration of voriconazole is within the target range. Historically, in some life-threatening situations like tuberculosis, where a suitable alternative is unavailable, rechallenge has been attempted. However, there have been no report on the rechallenge of voriconazole. We report cases of successful re-administration of voriconazole after liver toxicity.