Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective. (November 2020)

• Record Type: Journal Article
• Authors: Pinheiro, Ana P.; Schwartze, Michael; Kotz, Sonja A.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 118(2020)
• Page Start: 485
• Page End: 503
• Publication Date: 2020-11
• Subjects: Auditory verbal hallucinations -- Forward model -- Cerebellum -- Cognition -- Psychosis continuum; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2020.08.004
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Studies probing the role of the cerebellum in AVH were synthesized. Altered cerebellar function may contribute to changes in the forward model. These changes involve comparison of prediction and feedback, and forward model update. These changes could lead to external misattribution of self-generated sounds. Erratic sensory prediction could affect higher-level cognitive functions in AVH. Abstract: Auditory verbal hallucinations (AVH) ― experienced as voice hearing independent of a corresponding external sound source ― are a cardinal symptom of psychosis. Approximately 6-13% of healthy individuals also experience voice hearing. Despite numerous attempts to explain the neurofunctional mechanisms underlying AVH, they remain notoriously unexplained. However, evidence relates AVH to mechanistic changes in the forward model. This review synthesizes behavioral and neuroimaging studies exploring the central role of cerebellar circuitry in the forward model, with a particular focus on non-verbal and verbal auditory feedback. It confirms that erratic prediction of sensory consequences in voice and sound production is linked to impaired cerebellar function, which initiates AVH and affects higher-level cognitive functions. We propose new research directions linking the forward model to voice and sound feedback processing. We consider this review as a starting point for mapping mechanisms of the forward model to neurocognitive mechanisms underlying AVH.