Tissue-resident memory-like T cells in tumor immunity: Clinical implications. (June 2020) - Dhodapkar, Madhav V.
Abstract: Tissue-resident memory (TRM ) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. TRM - like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. TRM cells have also been shown to mediate anti-tumor immunity in murine models. Biology of TRM cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of TRM T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.