Is it time for biocatalysis in fragment-based drug discovery?. Issue 41 (12th October 2020)

• Record Type: Journal Article
• Authors: Ramsden, Jeremy I.; Cosgrove, Sebastian C.; Turner, Nicholas J.
• Is Part Of: Chemical science. Volume 11:Issue 41(2020)
• Page Start: 11104
• Page End: 11112
• Publication Date: 2020-10-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0sc04103c
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : This perspective discusses how biocatalysis could play an important role in the future fragment-based drug discovery. Abstract : The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.