Veratrilla baillonii Franch exerts anti-diabetic activity and improves liver injury through IRS/PI3K/AKT signaling pathways in type 2 diabetic db/db mice. (December 2020)

• Record Type: Journal Article
• Authors: He, Cai-Jing; Ma, Li-Qun; Iqbal, Muhammad Sarfaraz; Huang, Xian-Ju; Li, Jun; Yang, Guang-Zhong; Ihsan, Awais
• Is Part Of: Journal of functional foods. Volume 75(2020)
• Publication Date: 2020-12
• Subjects: Veratrilla baillonii Franch -- Diabetes mellitus -- Inflammatory cytokines -- Oxidant stress -- Hepatic injury -- PI3K/AKT signal pathway; ALB albumin -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- DM diabetes mellitus -- FINS fasting insulin -- GLUT2 glucose transporter-2 -- G6Pase glucose-6-phosphatase -- GP gentipicroside -- GSH glutathione -- HOMA-IR homeostatic model of insulin resistance -- IL-6 interleukin-6 -- IRS-1 insulin receptor substrate-1 -- LPS lipopolysaccharide -- MDA malondialdehyde -- NAFLD nonalcoholic fatty liver disease -- OGTT oral glucose tolerance tests -- PCK1 phosphoenolpyruvate carboxykinase 1 -- PDK1 phosphoinositide-dependent protein kinase -- PI3K phosphatidylinositol 3-kinase -- RBG random blood glucose -- ROS reactive oxygen species -- SOD superoxide dismutase -- SREBP-1 sterol regulatory element-binding protein-1 -- TBIL total bilirubin -- TNF-α tumor necrosis factor-alpha -- T2D type 2 diabetes -- WVBF water extract of V. baillonii; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.104204
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: The water extracts of Veratrilla baillonii Franch (WVBF) improves diabetes pathology. WVBF protects liver and kidney from injury in diabetic mice. WVBF alleviates the inflammation and oxidative stress. WVBF up-regulates IRS/PI3K/AKT/GLUT4 signaling pathways in diabetic mice. WVBF suppressed the hepatic gluconeogeness. Abstract: Veratrilla baillonii Franch ( V. baillonii ) is widely consumed as herbal tea or medicine for prevention and treatment of various disorders in the minority areas of Southwest China. In current study, the therapeutic activities of water extracts of V. baillonii (WVBF) and gentiopicroside (GP), a major bioactive compound of WVBF were investigated in db/db diabetic mice. After 6 weeks of WVBF or GP treatment, the efficacy was assessed by fasting blood glucose (FBG), oral glucose tolerance test (OGTT) and homeostasis model assessment (HOMA). The results indicated that WVBF or GP exerted anti-inflammation and anti-oxidant stress actions, and reduced the pathological damages of liver and kidney in db/db diabetic mice. The potential mechanisms were further determined, and the results displayed that IRS-1/PI3K/AKT signal pathway was involved in the anti-diabetic and hepatic protection activities of WVBF. These findings demonstrated that V. baillonii can be a good candidate for developing new anti-diabetic agents.