Adoptive T cell therapy: Boosting the immune system to fight cancer. (June 2020)

• Record Type: Journal Article
• Authors: Leon, Ernesto; Ranganathan, Raghuveer; Savoldo, Barbara
• Is Part Of: Seminars in immunology. Volume 49(2020)
• Publication Date: 2020-06
• Subjects: CAR-T cells -- T-cell receptor-modified (TCR) cells -- Cytolytic T cells (CTLs) -- Tumor infiltrating T cells (TILs) -- Adoptive cell therapy -- Hematologic malignancies; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2020.101437
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Cellular therapies have shown increasing promise as a cancer treatment. Encouraging results against hematologic malignancies are paving the way to move into solid tumors. In this review, we will focus on T-cell therapies starting from tumor infiltrating lymphocytes (TILs) to optimized T-cell receptor-modified (TCR) cells and chimeric antigen receptor-modified T cells (CAR-Ts). We will discuss the positive preclinical and clinical findings of these approaches, along with some of the persisting barriers that need to be overcome to improve outcomes.