Black soybean seed coat extract protects Drosophila melanogaster against Pb toxicity by promoting iron absorption. (December 2020)

• Record Type: Journal Article
• Authors: Li, Feixiang; Liu, Zhi-Hua; Tian, Xueke; Liu, Tengfei; Wang, Hui-Li; Xiao, Guiran
• Is Part Of: Journal of functional foods. Volume 75(2020)
• Publication Date: 2020-12
• Subjects: BSSCE -- Pb -- Iron deficiency -- ROS -- Drosophila melanogaster; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.104201
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Black soybean seed coat extract (BSSCE) protects Drosophila melanogaster against Pb toxicity. BSSCE relives Pb-induced oxidative stress in Drosophila melanogaster. BSSCE attenuated Pb-induced iron deficiency in Drosophila melanogaster. Iron restriction greatly suppressed the protective effects of BSSCE against Pb. Abstract: Black soybean seed coat extract (BSSCE) is a rich source of anthocyanins. This study was aimed at investigating the effects of BSSCE on Lead (Pb) toxicity. Here using Drosophila melanogaster, we show that defects caused by Pb was significantly ameliorated by BSSCE supplementation. Further studies showed that BSSCE attenuated Pb-induced systemic iron deficiency by modulating genes involved in iron absorption in the midgut. Additionally, BSSCE eliminated the reactive oxygen species (ROS) generated by Pb in the midgut through improving the antioxidant defense system. The protection of BSSCE against Pb was suppressed when dietary iron was restricted. These results suggest that promotion of iron absorption plays a dominant role in protective effects of BSSCE against Pb. The findings indicated that black soybean might be a promising functional food for preventing Pb toxicity or other iron deficiency related diseases, providing novel insight into mechanisms of antioxidants in protecting against heavy metal induced impairment.