The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1. (21st October 2020)

• Record Type: Journal Article
• Authors: Guo, Xuedan; Wang, Zhi; Sun, Qing; Sun, Chunhua; Hua, Hongxia; Huang, Qing
• Is Part Of: Acta biochimica et biophysica Sinica. Volume 52:Number 10(2020)
• Page Start: 1148
• Page End: 1155
• Publication Date: 2020-10-21
• Subjects: NSCLC -- anoikis resistance -- microRNA-1827 -- caveolin-1 -- A549 cell; Biochemistry -- Periodicals; Biophysics -- Periodicals; 572.05
• DOI: 10.1093/abbs/gmaa102
• Languages: English
• ISSNs: 1672-9145

Abstract

Abstract: Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC), and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis. In this study, we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC. The results showed that miR-1827 level was decreased in tumor tissues and cells and was correlated with tumor grade and lymph node (LN) metastasis. Overexpression of miR-1827 inhibited anchorage-independent growth and anoikis resistance in A549 cells. Bioinformatics and functional analysis identified that caveolin-1 (CAV-1) is directly targeted by miR-1827. Restoration of CAV-1 significantly attenuated miR-1827's effect on anoikis resistance in A549 cells. Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance, which might serve as a potential therapeutic target for metastatic NSCLC.