Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison. (18th September 2020)

• Record Type: Journal Article
• Authors: Leptourgos, Pantelis; Fortier-Davy, Martin; Carhart-Harris, Robin; Corlett, Philip R; Dupuis, David; Halberstadt, Adam L; Kometer, Michael; Kozakova, Eva; LarØi, Frank; Noorani, Tehseen N; Preller, Katrin H; Waters, Flavie; Zaytseva, Yuliya; Jardri, Renaud
• Is Part Of: Schizophrenia bulletin. Volume 46:Number 6(2020)
• Page Start: 1396
• Page End: 1408
• Publication Date: 2020-09-18
• Subjects: psychedelics -- psychosis -- hallucinations -- serotonin -- Bayesian -- computational; Schizophrenia -- Periodicals; Schizophrenia -- Research -- Periodicals; 616.898005
• DOI: 10.1093/schbul/sbaa117
• Languages: English
• ISSNs: 0586-7614

Abstract

Abstract: The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.