Morphological Transformation of Giant-Cell Tumor of Bone After Treatment with Denosumab: A Case Report. Issue 3 (July 2016)

• Record Type: Journal Article
• Authors: Zhang, Yaxia; Ilaslan, Hakan; Krishnaney, Ajit A.; Bauer, Thomas W.
• Is Part Of: JBJS case connector. Volume 6:Issue 3(2016)
• Publication Date: 2016-07
• Subjects: Orthopedic surgery -- Case studies -- Periodicals; Orthopedic surgery -- Periodicals; Orthopedics; Orthopedic Procedures; Orthopedic surgery; Periodicals; Electronic journals; Case studies; Periodicals; 616.7
• DOI: 10.2106/JBJS.CC.16.00015
• Languages: English
• ISSNs: 2160-3251

Abstract

Abstract : Case: Denosumab, an inhibitor of RANKL (receptor activator of nuclear factor κ-B ligand), was recently introduced for the treatment of giant-cell tumor of bone (GCTB). We describe the clinical, radiographic, and histological features of a GCTB of the spine in a 24-year-old woman that progressed after neoadjuvant treatment with denosumab. Disappearance of the multinuclear osteoclastic giant cells was accompanied by newly formed woven bone, which was deposited in interconnected strands with a prominent fibrovascular stroma that was histologically and radiographically similar to that of an osteoblastoma. Conclusion: Pathologists, radiologists, and surgeons should be aware of this post-treatment transformation to avoid misdiagnosis.