Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. (6th February 2020)

• Record Type: Journal Article
• Authors: Knudsen, Andreas D; Krebs-Demmer, Lisanne; Bjørge, Natascha I D; Elming, Marie B; Gelpi, Marco; Sigvardsen, Per E; Lebech, Anne-Mette; Fuchs, Andreas; Kühl, Jørgen T; Køber, Lars; Lundgren, Jens; Nordestgaard, Børge G; Kofoed, Klaus F; Nielsen, Susanne D
• Is Part Of: Journal of infectious diseases. Volume 222:Number 1(2020)
• Page Start: 54
• Page End: 61
• Publication Date: 2020-02-06
• Subjects: cardiac computed tomography -- comorbidity -- HIV -- obesity -- pericardial fat; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa057
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors. Methods: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography. Results: A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10–23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4 + nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, −6 to −25; P = .002) lower pericardial adipose tissue volume. Conclusions: Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population. Abstract : Among 587 persons with HIV and 587 uninfected controls, HIV status was independently associated with larger pericardial adipose tissue volume. Within persons with HIV, severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume.