Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis. (1st April 2020)

• Record Type: Journal Article
• Authors: Usategui-Martín, Ricardo; Carbonell, Cristina; Novo-Veleiro, Ignacio; Hernández-Pinchete, Sara; Mirón-Canelo, José Antonio; Chamorro, Antonio-Javier; Marcos, Miguel
• Is Part Of: Drug and alcohol dependence. Volume 209(2020)
• Publication Date: 2020-04-01
• Subjects: CYP2E1 -- CTRC -- Alcoholic pancreatitis -- Alcoholic chronic pancreatitis -- Meta-Analysis -- Polymorphism; Drug abuse -- Periodicals; Alcoholism -- Periodicals; 616.86
• DOI: 10.1016/j.drugalcdep.2020.107873
• Languages: English
• ISSNs: 0376-8716

Abstract

Highlights: Genetic predisposition plays an important role in the development of alcoholic pancreatitis. A meta-analysis was conducted to analyze the role of CYP2E1 and CTRC allelic variants in alcoholic pancreatitis. T allele of CTRC 180 C > T polymorphism and Trp variant of CTRC Arg254Trp were more prevalent in alcoholic pancreatitis. Abstract: Background: Genetic predisposition plays an important role in the development of alcoholic pancreatitis (AP), with previous studies suggesting that genetics variants in certain genes, such as CYP2E1 and CTRC, partially explain individual susceptibility to this disease. Therefore, the aim of this work was to conduct a systematic review and meta-analysis of existing studies that analyzed how polymorphisms within CYP2E1 and CTRC genes influence the risk of AP. Material and methods: We performed a systematic review of studies that analyzed the genotype distribution of CYP2E1 and CTRC allelic variants among patients with AP and a group of controls. A meta-analysis was conducted using a random effects model. Odds ratios (ORs) and their confidence intervals (CIs) were calculated. Results: The T allele of the CTRC 180 C > T variant was significantly more prevalent among patients with AP compared to all controls (OR = 1.79, 95% CI = 1.43–2.24; P < 0.00001) and healthy subjects (OR = 1.84, 95% CI = 1.46–2.31; P < 0.00001). The Trp variant of CTRC Arg254Trp polymorphism was also more prevalent in patients with AP; however, these results were not significant after excluding one study. We found no clear evidence that CYP2E1 -DraI or of CYP2E1 -RsaI/PstI polymorphisms modulate the risk of developing AP. Conclusions: Our meta-analysis supports that the T allele of CTRC 180C > T polymorphisms modulates the risk of alcoholic pancreatitis. No clear evidence was found for the remaining SNPs being associated with this disease.