Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model. Issue 13 (1st July 2020)

• Record Type: Journal Article
• Authors: Ahn, Se Hwan; Hwang, Kyu-Seok; Shin, Dae-Seop; Kim, Seong Soon; Yang, Jung Yoon; Lee, Byung Hoi; Bae, Eun Jung; Choi, Byeong Wook; Bae, Myung Ae; Ahn, Jin Hee
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 30:Issue 13(2020)
• Publication Date: 2020-07-01
• Subjects: Zebrafish -- Phenotype-based screening -- Reconstituted human skin -- Skin-whitening agent -- Cosmetic; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2020.127201
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A series of aryl sulfide derivatives was synthesized and evaluated for their anti-melanogenic activities. Several compounds, including 3e, 3i and 3q exhibited good anti-melanogenic activities. Among the derivatives, compound 3i showed good inhibitory effects against melanin synthesis and showed no toxicity in reconstituted human eye and skin tissues.