Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test. (1st June 2020)

• Record Type: Journal Article
• Authors: Kalyatanda, Gautam; Rand, Kenneth; Lindner, Martin S; Hong, David K; Sait Albayram, Mehmet; Gregory, Jason; Kresak, Jesse; Ibne, Karim M Ali; Cope, Jennifer R; Roy, Shantanu; Gary, Joy M; Reddy, Varalakshmi; Ahmed, Asim A
• Is Part Of: Open forum infectious diseases. Volume 7:Number 7(2020)
• Publication Date: 2020-06-01
• Subjects: Balamuthia mandrillaris -- granulomatous amoebic encephalitis -- next generation sequencing -- rapid diagnosis; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa189
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.