Case series of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy during extracorporeal life support. (October 2020)

• Record Type: Journal Article
• Authors: Bhandary, Prasad; Daniel, John M; Skinner, Sean C; Bacon, Matthew K; Hanna, Mina; Bauer, John A; Giannone, Peter; Ballard, Hubert O
• Is Part Of: Perfusion. Volume 35:Number 7(2020)
• Page Start: 700
• Page End: 706
• Publication Date: 2020-10
• Subjects: extracorporeal life support -- hypoxic-ischemic encephalopathy -- neonatal encephalopathy -- therapeutic hypothermia; Perfusion (Physiology) -- Periodicals; Blood -- Circulation, Artificial -- Periodicals; Heart -- Surgery -- Periodicals; Extracorporeal Circulation -- Periodicals; Perfusion -- Periodicals; Circulation extracorporelle -- Périodiques; Perfusion -- Périodiques; 617.41
• DOI: 10.1177/0267659119899521
• Languages: English
• ISSNs: 0267-6591

Abstract

Therapeutic hypothermia initiated within 6 hours of birth is currently the standard of care for the management of neonates with hypoxic-ischemic encephalopathy. Neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy are also at risk for severe respiratory failure and need for extracorporeal life support. The risks and benefits of therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support are still not well defined. We report our experience of a case series of six neonates who underwent therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support. We also report long-term neurodevelopmental follow-up from 6 to 24 months and add to the current body of evidence regarding feasibility, clinical experience, and short-term complications.