P0207PLASMA CHEMOKINE CXC MOTIF-LIGAND 16 AS A PREDICTOR OF RENAL PROGNOSIS IN IMMUNOGLOBULIN A NEPHROPATHY. (6th June 2020)

• Record Type: Journal Article
• Authors: Luo, Ran; Yang, Yi; Chang, Dan; Liu, Tingting; Li, Yue-Qiang; Dai, Wei; Zuo, Mei-Ying; Xu, Yu-lin; Zhang, Chun-Xiu; Xu, Gang; Ge, Shu-wang
• Is Part Of: Nephrology dialysis transplantation. Volume 35(2020)Supplement 3
• Publication Date: 2020-06-06
• Subjects: Nephrology -- Periodicals; Hemodialysis -- Periodicals; Kidneys -- Transplantation -- Periodicals; Hemodialysis; Kidneys -- Transplantation; Nephrology; Periodicals; 616.61
• DOI: 10.1093/ndt/gfaa142.P0207
• Languages: English
• ISSNs: 0931-0509

Abstract

Abstract: Background and Aims: A recognized non-invasive biomarker to improve risk stratification of IgA nephropathy (IgAN) patients is scarce. CXCL16 has been shown to play a key role in inflammatory disease as chemoattractant, adhesion and fibrosis factor. This study assessed the possibility of plasma CXCL16 as a potential biomarker in IgAN patients. Method: Plasma CXCL16 was measured in 230 patients with renal biopsied IgAN from 2012 to 2014. The patients were followed for 41.3 months with 50% reduction in eGFR or ESRD as end-points. Results: The plasma CXCL16 levels in IgAN patients were significantly correlated with the uric acid, estimated glomerular filtration rate and tubular atrophy/interstitial fibrosis score in multivariate analysis. In addition, the counts of CD4+ T cells, CD8+ T cells and CD20+ B cells in renal biopsies of IgAN patients were significantly correlated with the plasma CXCL16 levels, but not CD68+ macrophage. Finally, we concluded that patients with higher plasma CXCL16 levels had a higher risk of poor renal outcome compared with those with lower. No association was observed between the CXCL16 polymorphisms and clinical parameters including plasma CXCL16 levels and prognosis. Conclusion: Plasma CXCL16 levels were associated with clinical parameters, pathological damage, the CD4+ T cells, CD8+ T cells and CD20+ B cells infiltration in renal tissue and renal outcome in IgAN patients. Plasma CXCL16 might be a potential prognosis predictor in Chinese IgAN patients.