The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes. (4th March 2020)

• Record Type: Journal Article
• Authors: Sun, Deshun; Liu, Fei; Mitchell, Sharon E; Ma, Huanfei; Derous, Davina; Wang, Yingchun; Han, Jackie J D; Promislow, Daniel E L; Lusseau, David; Douglas, Alex; Speakman, John R; Chen, Luonan
• Editors: Anderson, Rozalyn
• Is Part Of: Journals of gerontology. Volume 75:Number 5(2020)
• Page Start: 858
• Page End: 866
• Publication Date: 2020-03-04
• Subjects: Calorie restriction -- Phase space reconstruction -- Attractors -- Gene expression; Geriatrics -- Periodicals; Gerontology -- Periodicals; 618.97
• DOI: 10.1093/gerona/glaa055
• Languages: English
• ISSNs: 1079-5006

Abstract

Abstract: Calorie restriction (CR) has a positive impact on health and life span. Previous work, however, does not reveal the whole underlying mechanism of behavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the behavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90-day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE), and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.