Use of Animal Models in Plant Sterol and Stanol Research. (27th November 2019)

• Record Type: Journal Article
• Authors: Solati, Zahra; Moghadasian, Mohammed H
• Is Part Of: Journal of AOAC International. Volume 98:Number 3(2015)
• Page Start: 691
• Page End: 696
• Publication Date: 2019-11-27
• Subjects: Agricultural chemistry -- Periodicals; Food -- Analysis -- Periodicals; 543
• DOI: 10.5740/jaoacint.SGESolati
• Languages: English
• ISSNs: 1060-3271

Abstract

Abstract: Cholesterol-lowering properties of plant sterols were reported approximately six decades ago. However, over the past couple of decades we have learnt more about other cardiovascular benefits of regular consumption of plant sterols and/or plant stanols. In particular a series of animal studies has consistently reported that dietary plant sterols and/or plant stanols or their fatty acid esters can reduce atherogenesis to a different extent in different animal models. Such effects may be mediated not only through reductions in LDL cholesterol levels, but also through other mechanisms including anti-inflammatory effects. In this manuscript, various animal models including mice, rabbits, hamsters, and others which have been used to establish cardiovascular benefits of plant sterols are discussed.