Case report: Synergetic effect of ischaemia and increased vagal tone inducing ventricular fibrillation in a patient with Brugada syndrome. Issue 4 (30th July 2020)

• Record Type: Journal Article
• Authors: Van Malderen, Sophie C H; Schultz, Carl J; Jordaens, Luc
• Editors: Hunter, Ross; Khan, Habib; Simovic, Stefan; Thomson, Ross
• Is Part Of: European heart journal. Volume 4:Issue 4(2020)
• Page Start: 1
• Page End: 5
• Publication Date: 2020-07-30
• Subjects: Brugada syndrome -- Ischaemia -- Myocardial infarction -- Vagal tone -- Ventricular arrhythmia -- Shock -- Case report; Cardiology -- Periodicals; Cardiology -- Case studies -- Periodicals; Heart -- Diseases -- Periodicals; Heart -- Diseases -- Case studies -- Periodicals; 616.12
• DOI: 10.1093/ehjcr/ytaa202
• Languages: English
• ISSNs: 2514-2119

Abstract

Abstract: Background: Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular tachycardia or fibrillation (VF). Case summary: A 72-year-old woman with BS and a stenosis on the proximal right coronary artery received several subsequent implantable cardioverter-defibrillator shocks due to VF during an episode of extreme nausea with vomiting. Discussion: This case report emphasizes on the synergetic effect of mild ischaemia and increased vagal tone on the substrate responsible for BS to create pathophysiological changes precipitating VF.