Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy. Issue 6 (24th April 2020)
- Record Type:
- Journal Article
- Title:
- Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy. Issue 6 (24th April 2020)
- Main Title:
- Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy
- Authors:
- Girardi, Paolo
Merler, Enzo
Ferrante, Daniela
Silvestri, Stefano
Chellini, Elisabetta
Angelini, Alessia
Luberto, Ferdinando
Fedeli, Ugo
Oddone, Enrico
Vicentini, Massimo
Barone-Adesi, Francesco
Cena, Tiziana
Mirabelli, Dario
Mangone, Lucia
Roncaglia, Francesca
Sala, Orietta
Menegozzo, Simona
Pirastu, Roberta
Azzolina, Danila
Tunesi, Sara
Miligi, Lucia
Perticaroli, Patrizia
Pettinari, Aldo
Cuccaro, Francesco
Nannavecchia, Anna Maria
Bisceglia, Lucia
Marinaccio, Alessandro
Pavone, Venere Leda Mara
Magnani, Corrado - Abstract:
- Abstract: Objectives: This study was performed with the aim of investigating the temporal patterns and determinants associated with mortality from asbestosis among 21 cohorts of Asbestos-Cement (AC) workers who were heavily exposed to asbestos fibres. Methods: Mortality for asbestosis was analysed for a cohort of 13 076 Italian AC workers (18.1% women). Individual cumulative asbestos exposure index was calculated by factory and period of work weighting by the different composition of asbestos used (crocidolite, amosite, and chrysotile). Two different approaches to analysis, based on Standardized Mortality Ratios (SMRs) and Age-Period-Cohort (APC) models were applied. Results: Among the considered AC facilities, asbestos exposure was extremely high until the end of the 1970s and, due to the long latency, a peak of asbestosis mortality was observed after the 1990s. Mortality for asbestosis reached extremely high SMR values [SMR: males 508, 95% confidence interval (CI): 446–563; females 1027, 95% CI: 771–1336]. SMR increased steeply with the increasing values of cumulative asbestos exposure and with Time Since the First Exposure. APC analysis reported a clear age effect with a mortality peak at 75–80 years; the mortality for asbestosis increased in the last three quintiles of the cumulative exposure; calendar period did not have a significant temporal component while the cohort effect disappeared if we included in the model the cumulative exposure to asbestos. Conclusions:Abstract: Objectives: This study was performed with the aim of investigating the temporal patterns and determinants associated with mortality from asbestosis among 21 cohorts of Asbestos-Cement (AC) workers who were heavily exposed to asbestos fibres. Methods: Mortality for asbestosis was analysed for a cohort of 13 076 Italian AC workers (18.1% women). Individual cumulative asbestos exposure index was calculated by factory and period of work weighting by the different composition of asbestos used (crocidolite, amosite, and chrysotile). Two different approaches to analysis, based on Standardized Mortality Ratios (SMRs) and Age-Period-Cohort (APC) models were applied. Results: Among the considered AC facilities, asbestos exposure was extremely high until the end of the 1970s and, due to the long latency, a peak of asbestosis mortality was observed after the 1990s. Mortality for asbestosis reached extremely high SMR values [SMR: males 508, 95% confidence interval (CI): 446–563; females 1027, 95% CI: 771–1336]. SMR increased steeply with the increasing values of cumulative asbestos exposure and with Time Since the First Exposure. APC analysis reported a clear age effect with a mortality peak at 75–80 years; the mortality for asbestosis increased in the last three quintiles of the cumulative exposure; calendar period did not have a significant temporal component while the cohort effect disappeared if we included in the model the cumulative exposure to asbestos. Conclusions: Among heaviest exposed workers, mortality risk for asbestosis began to increase before 50 years of age. Mortality for asbestosis was mainly determined by cumulative exposure to asbestos. … (more)
- Is Part Of:
- Annals of work exposures and health. Volume 64:Issue 6(2020)
- Journal:
- Annals of work exposures and health
- Issue:
- Volume 64:Issue 6(2020)
- Issue Display:
- Volume 64, Issue 6 (2020)
- Year:
- 2020
- Volume:
- 64
- Issue:
- 6
- Issue Sort Value:
- 2020-0064-0006-0000
- Page Start:
- 622
- Page End:
- 635
- Publication Date:
- 2020-04-24
- Subjects:
- asbestos exposure -- asbestos-related diseases -- asbestosis -- cohort mortality study -- retrospective assessment
Medicine, Industrial -- Periodicals
Industrial hygiene -- Periodicals
613.6205 - Journal URLs:
- https://academic.oup.com/annweh/issue ↗
http://www.oxfordjournals.org/ ↗ - DOI:
- 10.1093/annweh/wxaa037 ↗
- Languages:
- English
- ISSNs:
- 2398-7316
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 15138.xml