Expert-level automated sleep staging of long-term scalp electroencephalography recordings using deep learning. Issue 11 (1st June 2020)

• Record Type: Journal Article
• Authors: Abou Jaoude, Maurice; Sun, Haoqi; Pellerin, Kyle R; Pavlova, Milena; Sarkis, Rani A; Cash, Sydney S; Westover, M Brandon; Lam, Alice D
• Is Part Of: Sleep. Volume 43:Issue 11(2020)
• Publication Date: 2020-06-01
• Subjects: sleep staging -- deep learning -- EEG -- machine learning -- big data; Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsaa112
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Study Objectives: Develop a high-performing, automated sleep scoring algorithm that can be applied to long-term scalp electroencephalography (EEG) recordings. Methods: Using a clinical dataset of polysomnograms from 6, 431 patients (MGH–PSG dataset), we trained a deep neural network to classify sleep stages based on scalp EEG data. The algorithm consists of a convolutional neural network for feature extraction, followed by a recurrent neural network that extracts temporal dependencies of sleep stages. The algorithm's inputs are four scalp EEG bipolar channels (F3-C3, C3-O1, F4-C4, and C4-O2), which can be derived from any standard PSG or scalp EEG recording. We initially trained the algorithm on the MGH–PSG dataset and used transfer learning to fine-tune it on a dataset of long-term (24–72 h) scalp EEG recordings from 112 patients (scalpEEG dataset). Results: The algorithm achieved a Cohen's kappa of 0.74 on the MGH–PSG holdout testing set and cross-validated Cohen's kappa of 0.78 after optimization on the scalpEEG dataset. The algorithm also performed well on two publicly available PSG datasets, demonstrating high generalizability. Performance on all datasets was comparable to the inter-rater agreement of human sleep staging experts (Cohen's kappa ~ 0.75 ± 0.11). The algorithm's performance on long-term scalp EEGs was robust over a wide age range and across common EEG background abnormalities. Conclusion: We developed a deep learning algorithm that achieves human expert level sleep staging performance on long-term scalp EEG recordings. This algorithm, which we have made publicly available, greatly facilitates the use of large long-term EEG clinical datasets for sleep-related research.