Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial. (8th July 2015)

• Record Type: Journal Article
• Authors: McLean, Huong Q.; Belongia, Edward A.; Kieke, Burney A.; Meece, Jennifer K.; Fry, Alicia M.
• Is Part Of: Open forum infectious diseases. Volume 2:Number 3(2015)
• Publication Date: 2015-07-08
• Subjects: influenza -- oseltamivir; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofv100
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We conducted a double-blind, randomized trial of 134 outpatients with polymerase chain reaction-confirmed influenza to assess the effects of oseltamivir initiated 48–119 hours after illness onset. Oseltamivir treatment did not reduce illness duration, severity, or duration of virus detection. However, the power of this study was limited due to lower than expected enrollment.