Development of Mycobacterium avium Complex Lung Disease in Patients With Lung Cancer on Immune Checkpoint Inhibitors. (7th March 2020)

• Record Type: Journal Article
• Authors: Fujita, Kohei; Yamamoto, Yuki; Kanai, Osamu; Okamura, Misato; Nakatani, Koichi; Mio, Tadashi
• Is Part Of: Open forum infectious diseases. Volume 7:Number 3(2020)
• Publication Date: 2020-03-07
• Subjects: immune checkpoint inhibitors -- lung cancer -- Mycobacterium avium complex -- nontuberculous mycobacteria; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa067
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Immunotherapy with immune checkpoint inhibitors (ICIs), while ameliorating lung cancer, can cause infectious diseases, including tuberculosis, in addition to immune-related noninfectious complications. In the clinical setting, the efficacy of ICIs to treat mycobacterial infection remains controversial. We report 3 cases of acute Mycobacterium avium complex lung disease during immunotherapy with ICIs.