Frontal Beta Transcranial Alternating Current Stimulation Improves Reversal Learning. (2nd January 2020)

• Record Type: Journal Article
• Authors: Wischnewski, Miles; Joergensen, Mie L; Compen, Boukje; Schutter, Dennis J L G
• Is Part Of: Cerebral cortex. Volume 30:Number 5(2020)
• Page Start: 3286
• Page End: 3295
• Publication Date: 2020-01-02
• Subjects: electroencephalogram -- reversal learning -- transcranial alternating current stimulation -- beta power -- theta/beta ratio; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhz309
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: Electroencephalogram (EEG) studies suggest an association between beta (13–30 Hz) power and reversal learning performance. In search for direct evidence concerning the involvement of beta oscillations in reversal learning, transcranial alternating current stimulation (tACS) was applied in a double-blind, sham-controlled and between-subjects design. Exogenous oscillatory currents were administered bilaterally to the frontal cortex at 20 Hz with an intensity of 1 mA peak-to-peak and the effects on reward-punishment based reversal learning were evaluated in hundred-and-eight healthy volunteers. Pre- and post-tACS resting state EEG recordings were analyzed. Results showed that beta-tACS improved rule implementation during reversal learning and decreases left and right resting-state frontal theta/beta EEG ratios following tACS. Our findings provide the first behavioral and electrophysiological evidence for exogenous 20 Hz oscillatory electric field potentials administered over to the frontal cortex to improve reversal learning.