Full-spectrum responsive ZrO2-based phototheranostic agent for NIR-II photoacoustic imaging-guided cancer phototherapy. (3rd November 2020)

• Record Type: Journal Article
• Authors: Zhu, Chengyuan; Ding, Zhaoyang; Guo, Zhengxi; Guo, Xiaolu; Yang, Aijia; Li, Zhilang; Jiang, Bang-Ping; Shen, Xing-Can
• Is Part Of: Biomaterials science. Volume 8:Number 23(2020)
• Page Start: 6515
• Page End: 6525
• Publication Date: 2020-11-03
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm01482f
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A second near-infrared window (NIR-II) responsive, cancer targeting ZrO2 -based phototheranostic agent has been fabricated for imaging-guided precise synergetic phototherapy. Abstract : Second near-infrared (NIR-II) window responsive phototheranostic agents have a precise spatiotemporal potential for the diagnosis and treatment of cancer. In this study, a full-spectrum responsive ZrO2 -based phototheranostic agent was found to achieve NIR-II photoacoustic (PA) imaging-guided tumour-targeting phototherapy. Initially, the ZrO2 -based phototheranostic agent was fabricated through NaBH4 reduction to form boron-doped oxygen-deficient zirconia (ZrO2− x -B), an amino-functionalised SiO2 shell and a further covalent connection with hyaluronic acid (HA), namely, ZrO2− x -B@SiO2 -HA. In the ZrO2− x -B@SiO2 -HA system, the oxygen vacancy and boron doping resulted in full-spectrum absorption, enabling a high NIR-II photothermal conversion, high-resolution PA imaging ability and a remarkable production of reactive oxygen species (ROS). The surface modification of HA provided ZrO2− x -B@SiO2 -HA with water dispersibility and a targeting capability for CD44 overexpressed cancer cells. Furthermore, in vitro and in vivo experiments showed that NIR-II activated ZrO2− x -B@SiO2 -HA had a targeted photothermal/photodynamic effect for cancer elimination under the real-time guidance of NIR-II PAs. Hence, ZrO2− x -B@SiO2 -HA displays a precise NIR-II radiation-activated phototheranostic potential for PA imaging-guided cancer-targeting photothermal/photodynamic therapy.