The relationship between sleep disturbance and cognitive impairment: A population‐based cross‐sectional study: Epidemiology / Risk and protective factors in MCI and dementia. (7th December 2020)

• Record Type: Journal Article
• Authors: Gao, Fan; Gao, Ling; Wei, Shan; Dang, Liangjun; Shang, Suhang; Chen, Chen; Wang, Jin; Huo, Kang; Deng, Meiying; Wang, Jingyi; Qu, Qiumin
• Is Part Of: Alzheimer's & dementia. Volume 16(2020)Supplement 10
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-07
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.038278
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Growing evidence suggest that sleep disturbance is a risk factor for Alzheimer's disease, but the relationship between sleep disturbance and cognitive impairment is not clear. Method: This was a population‐based cross‐sectional study. A total of 1649 participants from a village in the suburbs of Xi'an, China were enrolled from January 3 to March 26, 2017. Sleep quality was assessed using the Pittsburgh sleep quality index (PSQI). Cognitive function was assessed with the mini‐mental state examination (MMSE). Univariate and multivariate analyses were used to analyze the relationships between sleep disturbance and cognitive impairment. Result: Among 1649 subjects, 110(6.7%) were diagnosed as cognitive impairment, and 960(58.2%) were diagnosed as sleep disturbance. In bivariate analysis, cognitive impairment was associated with insomnia)ρ=0.110; 95%CI=0.060‐0.154 ; P<0.01(, sleep efficiency)ρ=‐0.152; 95%CI=‐0.196‐ ‐0.105; P<0.01(, age)ρ=0.237; 95%CI=0.195‐0.279; P<0.01(and educational level )ρ=‐0.190; 95%CI=‐0.229‐ ‐0.149; P<0.01(. In the binary logistic regression, cognitive impairment was positively associated with the scales of PQSI (OR=1.072; 95%CI=1.016‐1.130; P=0.012). In the internal constitution of PQSI, cognitive impairment was positively associated with the sleep duration (OR=1.567; 95% CI=1.242‐1.979; P<0.01), step disturbances (OR=0.003; 95%CI=0.000‐0.023; P=0.017), and negatively associated with the habitual sleep efficiency (OR=1.068; 95%CI=1.012‐1.127; P<0.01). Cognitive impairment also was negatively associated with patients age (OR=0.130; 95%CI=0.069‐0.244; P<0.01). Conclusion: Sleep disturbances is associated with cognitive impairment. However, the causal relationships between sleep disturbances and cognitive impairment are not clear and need to be further studied.