A portable brainwave technology in detecting functional brain changes in aging and dementia: A pilot study on feasibility of the application in residential care older adults: Neuroimaging / New imaging methods. (7th December 2020)

• Record Type: Journal Article
• Authors: Arvan, Tara; Sepheri, Kattie; Hajra, Sujoy Ghosh; Pawlowski, Gabriela; Fickling, Shaun; D'arcy, Ryan C.N.; Song, Xiaowei
• Is Part Of: Alzheimer's & dementia. Volume 16(2020)Supplement 4
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-07
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.038658
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: A portable brainwave technology based on electroencephalography (EEG) / event‐related potential (ERP) has been established; i.e., the so called Brain Vital Signs ‐ BVS. Previous studies reported the development of the BVS framework and the characterization of BVS features in healthy younger adults. In the present study, we investigated the feasibility of application of this novel brainwave technology in older adult residents in long‐term care, and analyzed the relationship of the BVS scores in relation to age and dementia diagnosis. Method: Fifty‐one residents in long‐term care (mean age=81.4±9.5 years; range =56‐98; 66% female) with or without dementia (31:20) participated in the study. Each participant was tested, in their residence facility, at baseline and followed for up to 12 months during which two more tests were conducted. At each test time, participants were scanned twice using the BVS device, with which the electrodes placed on the frontal, central, and posterior sites along the midline of the head. Three ERP components, N100 (perception), P300 (attention), and N400 (cognition) were identified and converted into normalized comparative scores, based on which BVS sub‐scores assessing the amplitude, latency, and the area under the curve of each component were computed. The BVS total score was generated based on the sub‐scores applying a weighted algorithm. Inter‐rater reliability was examined using Intraclass Correlation Coefficient. The BVS scores were correlated with age, and compared for dementia and cognitive status. Result: Data were consistently collected from residential‐care older adults at each of the three time points with 100% success rate, suggesting the feasible application of the portably brainwave technology. Inter‐rater reliability rate was as high as 0.991‐1.000. The BVS total scores and several of the component scores were moderately related to age; e.g., Spearman correlation coefficient r=.262, p=.027 for P300 amplitude and r=‐.286, p=.016 for N400 latency. Some of the component scores differed by dementia status (e.g., t=‐2.03, p‐value= .046 for P300 latency). Conclusion: The study suggests that BVS can be feasibly applied in studying older residents in long‐term care. Ongoing analysis effort is to better understand age‐ and dementia‐ associated changes of the BVS scores for practical result interpretation.