Time‐frequency analysis in a working memory task in pre‐clinical stage and symptomatic stage of Alzheimer's disease: Developing topics. (7th December 2020)

• Record Type: Journal Article
• Authors: Doval, Sandra; Serrano, Noelia; Sanz, David López; Fernández, Ricardo Bruña; Losada, María Luisa Delgado; Higes, Ramón López; Dolado, Alberto Marcos; Maestú, Fernando
• Is Part Of: Alzheimer's & dementia. Volume 16(2020)Supplement 5
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-07
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.047583
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: The characteristic deterioration of the working memory (WM) in Alzheimer's disease (AD), is also one of its first symptoms. Alterations of oscillatory activity have been evidenced in frequency bands in underlined neuronal processes during WM task execution; in comparison to healthy individuals; since the first clinical manifestation of the disease – in patients with mild cognitive impairment (MCI) ‐ until the lasts phases of the disease. However, those alterations in the WM have not been widely studied in individuals that refer subjective cognitive decline (SCD) without objective evidence of cognitive deterioration. Method: The power of the underlined oscillatory activity during the maintenance period after an interruptor in a WM task was calculated by conducting a time‐frequency analysis. The results of three groups were compared: Controls (n = 46); SCD (n = 40), and MCI (n = 35). Result: Statistically significant results were found between‐group. Patients with MCI evidenced a decrease in alpha band in temporal, parietal and occipital sensors of both hemispheres in comparison to controls (clusterF = 3.22e+04, p= 4.99e‐05, η 2 =0.09). SCD group showed a decrease in beta band in left hemisphere in frontal and parietal sensors (clusterF=3.65e+03, p= 0.02, η 2 =0.06) in comparison to controls. SCD evidenced a decrement in theta band in the left hemisphere in fronto‐temporals sensors (clusterF=4.05e+03, p= 0.02, η 2 =0.06). Conclusion: As a conclusion, the subjective perception of SCD seems to have a biological correlate, assessable through alterations in the neuronal activity associated with WM maintenance.