Relationship between carotid atherosclerosis and plasma Aβ levels in patients with high risk of stroke: Biomarkers (non‐neuroimaging)/Plasma/Serum/Urine biomarkers. (7th December 2020)

• Record Type: Journal Article
• Authors: Wang, Anqi; Gao, Ling; Wei, Shan; Dang, Liangjun; Shang, Suhang; Chen, Chen; Wang, Jin; Huo, Kang; Deng, Meiying; Wang, Jingyi; Qu, Qiumin
• Is Part Of: Alzheimer's & dementia. Volume 16(2020)Supplement 5
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-07
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.038711
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Growing evidence indicated that vascular factors contributed to the pathogenesis of Alzheimer's disease (AD), but the relationship of atherosclerosis and AD is unclear. As Amyloid‐β (Aβ) deposition in the brain is a main pathophysiology of AD and plasma Aβ is closely related to Aβ deposition in the brain. In present study, we investigated the relationship between carotid atherosclerosis and plasma Aβ levels. Method: Patients with high risk of stroke were from community stroke screening in Qubao Village, Xi'an. Carotid ultrasound was used to detect carotid atherosclerosis. Venous blood was collected on an empty stomach in the morning. Plasma Aβ1‐40 and Aβ1‐42 levels were measured by ELISA. Univariate and multivariate analysis were used to investigated carotid atherosclerosis and plasma Aβ1‐40 and Aβ1‐42 levels. Result: Among 222 participants underwent carotid ultrasound, 149 had carotid atherosclerosis (49.01%). Univariate analysis showed that plasma Aβ1‐40 level and Aβ1‐42 level had no significant differences between carotid atherosclerosis group and non‐carotid atherosclerosis group (53.15 ± 8.77 vs. 50.96 ± 8.79 pg/ml, P =0.083; 41.07 ± 6.51 vs. 39.95 ± 5.93 pg/ml, P =0.217). Multivariate linear regression analysis showed that plasma Aβ1‐40 (b=1.832, p = 0.213), plasma Aβ1‐42 (b=1.605, P =0.131) and plasma Aβ1‐40 /Aβ1‐42 ratio (b=‐0.012, P = 0.829) had no significant difference between two groups in the total population. However, in the non‐hypertensive population, plasma Aβ1‐40 and Aβ1‐42 were significantly higher in the carotid atherosclerosis group than those in the non‐carotid atherosclerosis group (b=6.774, 95% CI: 2.691‐10.858 pg/ml, P =0.001; b=3.408, 95% CI: 0.309‐6.508 pg/ml, P =0.032). Conclusion: Among patients with high risk of stroke, carotid atherosclerosis was associated with higher plasma Aβ levels in non‐hypertension group. These indicated that atherosclerosis may be related to AD, and the relationships may be confounded by hypertension.