2020 annual report of Japanese brain bank network for neuroscience research: Human neuropathology/clinico‐pathologic correlations. (7th December 2020) - Murayama, Shigeo
Abstract: Background: The Japanese Society of Neuropathology (JSNP) stared the Brain Bank Committee in 1986 and has made continuous effort to establish all Japan Brain Bank Network. Method: The Brain Bank for Aging Research was established in 1999, including 1, 200 frozen brain and peripheral tissues from cohort of aging community and 130 neurodegenerative disorders from all over Japan. BBAR invited members of JSNP to form a brain bank network of Western style, consisting of brain donation, open resource, quality control including neuropathological diagnostic criteria in 2010. Result: Three brain banks: National Center of Neurology and Psychiatry (NCNP), Mihara Memorial Hospital (MMH) and Fukushimura Hospital (FH) participated the Japanese Brain Bank Network for Neuroscience Research (JBBNNR) and received funding of Ministry of Education, Culture, Sports and Technology, Japan. All resources were from general autopsy and had clinical and radiological information. NCNP was for neurodegenerative and muscle disorders, MMH for ALS, cerebrovascular disorders and prion disease and FH for terminal cases of dementia and aging. In 2020, the Graduate School of Medicine, Osaka University will participate the network for developmental disorders. In japan, autopsy was the main source of human research and our project will be effective for ADNI‐ type clinical study constructing bioresource as well as postmortem human tissue. Conclusion: Our brain bank project contributes to establish neurobiobank in Japan, bridging genome, bioresource, neuroimages and postmortem human tissue. The main target is human aging and the next step will be human development.