The value of intravoxel incoherent motion imaging in predicting the survival of patients with astrocytoma. (March 2021)

• Record Type: Journal Article
• Authors: Zhu, Lina; Wu, Jiang; Zhang, Hui; Niu, Heng; Wang, Le
• Is Part Of: Acta radiologica. Volume 62:Number 3(2021)
• Page Start: 423
• Page End: 429
• Publication Date: 2021-03
• Subjects: Intravoxel incoherent motion imaging -- cerebral astrocytoma -- survival; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185120926907
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: The evaluation of the prognosis of gliomas may have great value in individualized treatment. Purpose: To evaluate the value of intravoxel incoherent motion (IVIM) in predicting the survival of patients with astrocytoma and comparing it to apparent diffusion coefficients (ADC). Material and Methods: Sixty patients with pathologically confirmed cerebral astrocytomas underwent IVIM scans before any treatment was performed. Patients were divided into death group and survival group according to a two-year follow-up. ADC and quantitative parameters of IVIM including D, D*, and f were measured. Independent sample t test was used to compare the two groups of parameters. The accuracy of each parameter for two-year survival rate was analyzed by receiver operating characteristic (ROC) curve and Kaplan–Meier survival curves. The correlation between quantitative parameters and survival days was analyzed by Pearson correlation analysis. Results: The ADC, D*, and f values were statistically significant different between the death and the survival groups ( P < 0.05). The AUC of the ADC, D*, and f were 0.811, 0.858, and 0.892, respectively. The ADC cut-off value of 0.668 × 10 −3 mm 2 /s corresponded to 82.6% sensitivity and 73% specificity. The D* cut-off value of 3.913 × 10 −3 mm 2 /s corresponded to 78.4% sensitivity and 87% specificity. The f cut-off value of 0.487 corresponded to 83.8% sensitivity and 87% specificity. Significant log rank test was performed for each parameter to predict overall survival ( P < 0.05). There was a correlation between ADC ( r = 0.625, P = 0.023), D* ( r = −0.655, P = 0.012), f ( r = −0.725, P = 0.000) and survival days. Conclusion: The D* and f values demonstrated great potential in predicting the two-year survival rate for patients with astrocytoma.