Resting state functional connectivity associated with financial capacity in mild cognitive impairment: Neuroimaging / New imaging methods. (7th December 2020)

• Record Type: Journal Article
• Authors: Nowrangi, Milap; Naaz, Farah; Chen, Liuyi; Outen, John D.; Bakker, Arnold; Rosenberg, Paul B.
• Is Part Of: Alzheimer's & dementia. Volume 16(2020)Supplement 4
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-07
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.045635
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Financial capacity (FC) is a complex, multi‐dimensional neurocognitive construct that is commonly impaired and disables older individuals with cognitive impairment but the underlying mechanisms are not well understood. Resting state functional connectivity was measured in individuals with mild cognitive impairment (MCI) and impaired FC compared to cognitively normal controls (NC) in order to identify relevant network components that may help drive future interventions. Method: Resting state functional MRI scans were obtained from individuals with MCI (N=17) and age, gender, and education matched NC (N=15). Table 1. All participants completed the Financial Capacity Instrument (FCI) and neuropsychological assessment. Based on previously reported imaging findings in this population, the left Angular Gyrus (lAG) was used as the seed region in functional connectivity measurements. Connectivity beta values (Fisher transformed correlation coefficients) were calculated for each connection that showed significantly altered connectivity between control and MCI cases. A Pearson's correlation was calculated between the connectivity beta values from relevant regions and cognitive measures. Result: A total of 26 brain regions showed significant increased functional connectivity (p <0.05 uncorrected) with the lAG in NC compared to MCI. Of these regions 14 were identified as relevant to higher‐level cognitive function and carried forward in the correlation analysis (Fig. 1). Pearson's correlation showed significant negative association between the FCI and increased connectivity with the right temporal fusiform cortex (rTFC, r = ‐0.455, p = 0.009); negative correlation between Clock drawing and increased connectivity with the intraparietal sulcus ( r = ‐0.38, p = 0.03); positive correlation between Trails B and increased connectivity with postcentral gyrus ( r = 0.39, p = 0.03) and left central operculum ( r = 0.36, p = 0.04). Table 2. Conclusion: There is a significant correlation between a well‐validated measure of FC and increased functional connectivity between the lAG and the rTFC in controls compared to MCI. This novel finding suggests that integration of visuoperception, memory, and mathematical function is critical for FC. No other significant correlation between the lAG and rTFC was found with other tests of executive function or visuospatial cognition.