Clinical analysis of 132 cases COVID-19 from Wuhan. Issue 44 (30th October 2020)

• Record Type: Journal Article
• Authors: Li, Hai-yan; Wang, Jin-wei; Xu, Li-wei; Zhao, Xu-ling; Feng, Jia-xi; Xu, You-zu
• Other Names: Bellou. Abdelouahab section editor.
• Is Part Of: Medicine. Volume 99:Issue 44(2020)
• Publication Date: 2020-10-30
• Subjects: clinical characteristics -- coronavirus -- COVID-19 -- Treatment; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000022847
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Numerous cases of pneumonia from a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China during December 2019. We determined the correlations of patient parameters with disease severity in patients with COVID-19. A total of 132 patients from Wuhan Fourth Hospital who had COVID-19 from February 1 to February 29 in 2020 were retrospectively analyzed. Ninety patients had mild disease, 32 had severe disease, and 10 had critical disease. The severe/critical group was older ( P < .05), had a higher proportion of males ( P < .05), and had a greater mortality rate (0% vs 61.9%, P < .05). The main symptoms were fever (n = 112, 84.8%) and cough (n = 96, 72.7%). Patients were treated with antiviral agents (n = 94, 71.2%), antibiotics (n = 92, 69.7%), glucocorticoids (n = 46, 34.8%), intravenous immunoglobulin (n = 38, 27.3%), and/or traditional Chinese medicine (n = 40, 30.3%). Patients in the severe/critical group received mechanical ventilation (n = 22, 16.7%) or high-flow nasal can-nula oxygen therapy (n = 6, 4.5%). Chest computed tomography (CT) indicated bilateral pneumonia in all patients. Relative to the mild group, the severe/critical group had higher levels of leukocytes, C-reactive protein (CRP), procalcitonin (PCT), D-dimer, B-type natriuretic peptide (BNP), liver enzymes, and myocardial enzymes ( P < .05), and decreased levels of lymphocytes and blood oxygen partial pressure ( P < .05). The main clinical symptoms of patients from Wuhan who had COVID-19 were fever and cough. Patients with severe/critical disease were more likely to be male and elderly. Disease severity correlated with increased leukocytes, CRP, PCT, BNP, D-dimer, liver enzymes, and myocardial enzymes, and with decreased lymphocytes and blood oxygen partial pressure.