Allostery of DNA nanostructures controlled by enzymatic modifications. Issue 13 (11th June 2020)
- Record Type:
- Journal Article
- Title:
- Allostery of DNA nanostructures controlled by enzymatic modifications. Issue 13 (11th June 2020)
- Main Title:
- Allostery of DNA nanostructures controlled by enzymatic modifications
- Authors:
- Yan, Qi
Wang, Yaqi
Shi, Jile
Wei, Bryan - Abstract:
- Abstract: Allostery is comprehensively studied for natural macromolecules, such as proteins and nucleic acids. Here, we present controllable allostery of synthetic DNA nanostructure–enzyme systems. Rational designs of the synthetic allosteric systems are based on an in-depth understanding of allosteric sites with several types of strand placements, whose varying stacking strengths determine the local conformation and ultimately lead to a gradient level of allosteric transition. When enzymes in a molecular cloning toolbox such as DNA polymerase, exonuclease and ligase are applied to treat the allosteric sites, the resulting local conformational changes propagate through the entire structure for a global allosteric transition.
- Is Part Of:
- Nucleic acids research. Volume 48:Issue 13(2020)
- Journal:
- Nucleic acids research
- Issue:
- Volume 48:Issue 13(2020)
- Issue Display:
- Volume 48, Issue 13 (2020)
- Year:
- 2020
- Volume:
- 48
- Issue:
- 13
- Issue Sort Value:
- 2020-0048-0013-0000
- Page Start:
- 7595
- Page End:
- 7600
- Publication Date:
- 2020-06-11
- Subjects:
- Nucleic acids -- Periodicals
Molecular biology -- Periodicals
572.805 - Journal URLs:
- http://nar.oxfordjournals.org/ ↗
http://www.ncbi.nlm.nih.gov/pmc/journals/4 ↗
http://ukcatalogue.oup.com/ ↗
http://firstsearch.oclc.org ↗ - DOI:
- 10.1093/nar/gkaa488 ↗
- Languages:
- English
- ISSNs:
- 0305-1048
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6183.850000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 15109.xml