Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19. (19th August 2020)

• Record Type: Journal Article
• Authors: Guervilly, Christophe; Burtey, Stephane; Sabatier, Florence; Cauchois, Raphaël; Lano, Guillaume; Abdili, Evelyne; Daviet, Florence; Arnaud, Laurent; Brunet, Philippe; Hraiech, Sami; Jourde-Chiche, Noémie; Koubi, Marie; Lacroix, Romaric; Pietri, Léa; Berda, Yaël; Robert, Thomas; Degioanni, Clara; Velier, Mélanie; Papazian, Laurent; Kaplanski, Gilles; Dignat-George, Françoise
• Is Part Of: Journal of infectious diseases. Volume 222:Number 11(2020)
• Page Start: 1789
• Page End: 1793
• Publication Date: 2020-08-19
• Subjects: circulating endothelial cells -- COVID-19 -- endothelial injury; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa528
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.