A novel fully automated MRI-based deep-learning method for classification of 1p/19q co-deletion status in brain gliomas. Issue 1 (17th July 2020)

• Record Type: Journal Article
• Authors: Yogananda, Chandan Ganesh Bangalore; Shah, Bhavya R; Yu, Frank F; Pinho, Marco C; Nalawade, Sahil S; Murugesan, Gowtham K; Wagner, Benjamin C; Mickey, Bruce; Patel, Toral R; Fei, Baowei; Madhuranthakam, Ananth J; Maldjian, Joseph A
• Is Part Of: Neuro-oncology advances. Volume 2:Issue 1(2020)
• Publication Date: 2020-07-17
• Subjects: deep learning -- glioma -- 1p/19 co-deletion; 616.99481
• DOI: 10.1093/noajnl/vdaa066
• Languages: English
• ISSNs: 2632-2498

Abstract

Abstract: Background: One of the most important recent discoveries in brain glioma biology has been the identification of the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion status as markers for therapy and prognosis. 1p/19q co-deletion is the defining genomic marker for oligodendrogliomas and confers a better prognosis and treatment response than gliomas without it. Our group has previously developed a highly accurate deep-learning network for determining IDH mutation status using T2-weighted (T2w) MRI only. The purpose of this study was to develop a similar 1p/19q deep-learning classification network. Methods: Multiparametric brain MRI and corresponding genomic information were obtained for 368 subjects from The Cancer Imaging Archive and The Cancer Genome Atlas. 1p/19 co-deletions were present in 130 subjects. Two-hundred and thirty-eight subjects were non-co-deleted. A T2w image-only network (1p/19q-net) was developed to perform 1p/19q co-deletion status classification and simultaneous single-label tumor segmentation using 3D-Dense-UNets. Three-fold cross-validation was performed to generalize the network performance. Receiver operating characteristic analysis was also performed. Dice scores were computed to determine tumor segmentation accuracy. Results: 1p/19q-net demonstrated a mean cross-validation accuracy of 93.46% across the 3 folds (93.4%, 94.35%, and 92.62%, SD = 0.8) in predicting 1p/19q co-deletion status with a sensitivity and specificity of 0.90 ± 0.003 and 0.95 ± 0.01, respectively and a mean area under the curve of 0.95 ± 0.01. The whole tumor segmentation mean Dice score was 0.80 ± 0.007. Conclusion: We demonstrate high 1p/19q co-deletion classification accuracy using only T2w MR images. This represents an important milestone toward using MRI to predict glioma histology, prognosis, and response to treatment.