Pharmacogenomic clinical decision support design and multi-site process outcomes analysis in the eMERGE Network. (24th December 2018)

• Record Type: Journal Article
• Authors: Herr, Timothy M; Peterson, Josh F; Rasmussen, Luke V; Caraballo, Pedro J; Peissig, Peggy L; Starren, Justin B
• Is Part Of: Journal of the American Medical Informatics Association. Volume 26:Number 2(2019)
• Page Start: 143
• Page End: 148
• Publication Date: 2018-12-24
• Subjects: pharmacogenomics -- pharmacogenetics -- clinical decision support -- precision medicine -- process outcomes; Medical informatics -- Periodicals; Information Services -- Periodicals; Medical Informatics -- Periodicals; Médecine -- Informatique -- Périodiques; Informatica; Geneeskunde; Informatique médicale; Computer network resources; Electronic journals; 610.285
• DOI: 10.1093/jamia/ocy156
• Languages: English
• ISSNs: 1067-5027

Abstract

Abstract: To better understand the real-world effects of pharmacogenomic (PGx) alerts, this study aimed to characterize alert design within the eMERGE Network, and to establish a method for sharing PGx alert response data for aggregate analysis. Seven eMERGE sites submitted design details and established an alert logging data dictionary. Six sites participated in a pilot study, sharing alert response data from their electronic health record systems. PGx alert design varied, with some consensus around the use of active, post-test alerts to convey Clinical Pharmacogenetics Implementation Consortium recommendations. Sites successfully shared response data, with wide variation in acceptance and follow rates. Results reflect the lack of standardization in PGx alert design. Standards and/or larger studies will be necessary to fully understand PGx impact. This study demonstrated a method for sharing PGx alert response data and established that variation in system design is a significant barrier for multi-site analyses.