Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques. (3rd August 2020)

• Record Type: Journal Article
• Authors: Koo, Bon-Sang; Oh, Hanseul; Kim, Green; Hwang, Eun-Ha; Jung, Hoyin; Lee, Youngjeon; Kang, Philyong; Park, Jae-Hak; Ryu, Choong-Min; Hong, Jung Joo
• Is Part Of: Journal of infectious diseases. Volume 222:Number 10(2020)
• Page Start: 1596
• Page End: 1600
• Publication Date: 2020-08-03
• Subjects: macaques -- lymphopenia -- pneumonia -- SARS-CoV-2; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa486
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.