T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019. (7th May 2020)

• Record Type: Journal Article
• Authors: Jiang, Mei; Guo, Yang; Luo, Qing; Huang, ZiKun; Zhao, Rui; Liu, ShuYuan; Le, AiPing; Li, JunMing; Wan, LaGen
• Is Part Of: Journal of infectious diseases. Volume 222:Number 2(2020)
• Page Start: 198
• Page End: 202
• Publication Date: 2020-05-07
• Subjects: SARS-CoV2 -- lymphocyte subsets -- diagnosis -- prognosis; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa252
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3 + T cells, CD4 + T cells, CD8 + T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4 + T cells but a severe decrease in CD8 + T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8 + T and CD4 + T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity. Abstract : Our results demonstrated that significantly decreased T-cell subset counts were related to the severity and prognosis of COVID-19. Consequently, the counts of CD8 + and CD4 + T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.