Individual-Level Identification of Gene Expression Associated with Volume Differences among Neocortical Areas. (18th March 2020)

• Record Type: Journal Article
• Authors: Fu, Jilian; Liu, Feng; Qin, Wen; Xu, Qiang; Yu, Chunshui
• Is Part Of: Cerebral cortex. Volume 30:Number 6(2020)
• Page Start: 3655
• Page End: 3666
• Publication Date: 2020-03-18
• Subjects: cerebral cortex -- functional annotation -- gene expression -- magnetic resonance imaging -- mental disorder; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhz333
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: The human cerebral cortex is the source of many complex behaviors and is a vulnerable target of various neuropsychiatric disorders, but transcriptional profiles linked to cerebral cortical volume (CCV) differences across brain areas remain unknown. Here, we screened CCV-related genes using an across-sample spatial correlation analysis in 6 postmortem brains and then individually validated these correlations in 1091 subjects with different ages and ethnicities. We identified 62 genes whose transcriptional profiles were repeatedly associated with CCV in more than 90% of individuals. CCV-related genes were specifically expressed in neurons and in developmental periods from middle childhood to young adulthood, were enriched in ion channels and developmental processes, and showed significant overlap with genes linked to brain functional activity and mental disorders. The identified genes represent the conserved transcriptional architecture of the human cerebral cortex, suggesting a link between conserved gene transcription and neocortical structural properties.