Latent tuberculosis infection prevalence in rural Madagascar. (5th August 2020)

• Record Type: Journal Article
• Authors: Sadananda, Gouri; Knoblauch, Astrid M; Andriamiadanarivo, Andry; Razafindrina, Kimmerling; Ambinintsoa, Ideal; Rabetombosoa, Roger Mario; Pando, Christine E; Tsang, Lai Yu; Small, Peter M; Rakotosamimanana, Niaina; Grandjean Lapierre, Simon
• Is Part Of: Transactions of the Royal Society of Tropical Medicine and Hygiene. Volume 114:Number 11(2020)
• Page Start: 883
• Page End: 885
• Publication Date: 2020-08-05
• Subjects: HIV -- latent TB infection -- Madagascar -- TB -- tuberculin skin test; Tropical medicine -- Periodicals; 616.9883
• DOI: 10.1093/trstmh/traa054
• Languages: English
• ISSNs: 0035-9203

Abstract

Abstract: Background: Understanding latent Mycobacterium tuberculosis infection (LTBI) prevalence is crucial for the design of TB control strategies. There are no data on LTBI in rural Madagascar. Methods: Tuberculin skin tests were performed in 98 adults aged >15 y in five rural villages in the Ifanadiana district, Madagascar. Results: Of adults, 78.6% were positive for LTBI, ranging between 28.6% and 95.0% among villages. The majority (65.3%) showed an induration reaction of >15 mm. Conclusions: LTBI prevalence is high in rural Madagascar. Long-term TB control strategies including LTBI testing and treatment must account for high and heterogeneous prevalence in remote, underdeveloped areas.