Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice. (23rd May 2020)

• Record Type: Journal Article
• Authors: Bao, Linlin; Gao, Hong; Deng, Wei; Lv, Qi; Yu, Haisheng; Liu, Mingya; Yu, Pin; Liu, Jiangning; Qu, Yajin; Gong, Shuran; Lin, Kaili; Qi, Feifei; Xu, Yanfeng; Li, Fengli; Xiao, Chong; Xue, Jing; Song, Zhiqi; Xiang, Zhiguang; Wang, Guanpeng; Wang, Shunyi; Liu, Xing; Zhao, Wenjie; Han, Yunlin; Wei, Qiang; Qin, Chuan
• Is Part Of: Journal of infectious diseases. Volume 222:Number 4(2020)
• Page Start: 551
• Page End: 555
• Publication Date: 2020-05-23
• Subjects: SARS-COV-2 -- transmission routes -- close contact -- respiratory droplets -- hACE2 transgenic mice -- aerosol; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa281
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations. Abstract : Severe acute respiratory syndrome coronavirus 2 can be highly transmitted among naive angiotensin-converting enzyme 2 mice via close-contact spreading by respiratory droplets. However, these mice cannot be experimentally infected through aerosol inoculation unless it is continued for 25 minutes with a high viral concentration.