Multiple developmental pathways lead to the generation of CD4 T-cell memory. (7th August 2020)

• Record Type: Journal Article
• Authors: Hojyo, Shintaro; Tumes, Damon; Murata, Akihiko; Tokoyoda, Koji
• Is Part Of: International immunology. Volume 32:Number 9(2020)
• Page Start: 589
• Page End: 595
• Publication Date: 2020-08-07
• Subjects: antigen -- bone marrow -- effector -- memory T helper cell -- niche; Immunology -- Periodicals; 616.079
• DOI: 10.1093/intimm/dxaa051
• Languages: English
• ISSNs: 0953-8178

Abstract

Abstract: Long-term immunological memory mediated by CD4 T cells provides a rapid protection against previously encountered pathogens or antigens. However, it is still controversial how memory CD4 T cells are generated and maintained. Unclear definitions of T-cell memory may be partially responsible for this controversy. It is becoming clear that diverse pathways are responsible for the differentiation and long-term persistence of memory T cells. We herein discuss the diversity of memory cell generation, describing a novel population of resting memory CD4 T cells and their precursors.