Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress. (17th January 2020)

• Record Type: Journal Article
• Authors: Han, Feng; Dou, Meng; Wang, Yuxiang; Xu, Cuixiang; Li, Yang; Ding, XiaoMing; Xue, WuJun; Zheng, Jin; Tian, Puxun; Ding, Chenguang
• Is Part Of: Acta biochimica et biophysica Sinica. Volume 52:Number 2(2020)
• Page Start: 125
• Page End: 132
• Publication Date: 2020-01-17
• Subjects: cordycepin -- renal ischemia/reperfusion injury -- inflammation -- apoptosis -- oxidative stress; Biochemistry -- Periodicals; Biophysics -- Periodicals; 572.05
• DOI: 10.1093/abbs/gmz145
• Languages: English
• ISSNs: 1672-9145

Abstract

Abstract: Cordycepin (3′-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps . It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal ischemia/reperfusion injury (I/R) are still unknown. In the present study, rats were subject to I/R and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal I/R injury. The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury. Mechanistic studies showed that cordycepin significantly regulated inflammation, apoptosis, and oxidative stress. These data provide new insights for investigating the natural product with the nephroprotective effect against I/R, which should be developed as a new therapeutic agent for the treatment of I/R in the future.