Practicing Antimicrobial Stewardship: De-Escalating Antibiotics in Patients With Acute Myeloid Leukemia and Neutropenic Fever. (21st April 2020)

• Record Type: Journal Article
• Authors: Fuller, Risa; Moshier, Erin; Jacobs, Samantha E; Tremblay, Douglas; Lancman, Guido; Coltoff, Alexander; Caro, Jessica; Mascarenhas, John; Rana, Meenakshi
• Is Part Of: Open forum infectious diseases. Volume 7:Number 5(2020)
• Publication Date: 2020-04-21
• Subjects: acute myeloid leukemia -- antimicrobial stewardship -- neutropenic fever; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa138
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We compared risk of recurrent fever in patients with acute myeloid leukemia undergoing induction chemotherapy with febrile neutropenia without an infectious source in which antibacterials were de-escalated before neutrophil recovery versus continued. There was less recurrent fever when antibacterials were de-escalated early with no increased adverse events.