Radiosurgery for Unruptured Intervention-Naïve Pediatric Brain Arteriovenous Malformations. Issue 2 (13th January 2020)

• Record Type: Journal Article
• Authors: Chen, Ching-Jen; Lee, Cheng-Chia; Kano, Hideyuki; Kearns, Kathryn N; Ding, Dale; Tzeng, Shih-Wei; Atik, Ahmet Fatih; Joshi, Krishna; Huang, Paul P; Kondziolka, Douglas; Ironside, Natasha; Mathieu, David; Iorio-Morin, Christian; Grills, Inga S; Quinn, Thomas J; Siddiqui, Zaid A; Marvin, Kim; Feliciano, Caleb; Starke, Robert M; Faramand, Andrew; Barnett, Gene; Lunsford, L Dade; Sheehan, Jason P
• Is Part Of: Neurosurgery. Volume 87:Issue 2(2020)
• Page Start: 368
• Page End: 376
• Publication Date: 2020-01-13
• Subjects: Pediatric -- Stroke -- Arteriovenous malformation -- Radiosurgery -- Unruptured -- Radiation; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyz558
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: BACKGROUND: Long-term data regarding stereotactic radiosurgery (SRS) as a standalone therapy for unruptured pediatric brain arteriovenous malformations (AVMs) are incompletely defined. OBJECTIVE: To evaluate, in a multicenter, retrospective cohort study, the outcomes after SRS for unruptured, intervention-naïve pediatric AVMs. METHODS: To retrospectively analyze the International Radiosurgery Research Foundation pediatric AVM database from 1987 to 2018. Pediatric patients with unruptured, previously untreated AVMs who underwent SRS were included. The primary endpoint was a composite of hemorrhagic stroke, death, or permanently symptomatic radiation-induced changes. RESULTS: The study cohort comprised 101 patients (mean follow-up 80.8 mo). The primary endpoint occurred in 14%, comprising hemorrhagic stroke, death, and permanent radiation-induced changes in 6%, 3%, and 8%, respectively. Estimated probabilities of the primary endpoint were 5.2%, 10.8%, and 23.0% at 2, 5, and 10 yr, respectively. Estimated probabilities of AVM obliteration at 5 and 10 yr were 64% and 82%, respectively. Single SRS treatment ( P = .007) and higher margin dose ( P = .005) were predictors of obliteration. Subgroup analysis of Spetzler-Martin grade I-III AVMs estimated primary endpoint probabilities of 3.7%, 8.4%, and 18.7% at 2, 5, and 10 yr, respectively. CONCLUSION: Treatment of unruptured, intervention-naïve AVMs in the pediatric population with SRS carries an approximately 2% annual risk of morbidity and mortality, which appears to plateau after 10 yr. The poorly described natural history of pediatric AVMs renders any comparison of SRS vs conservative management imperfect. Graphical Abstract: