Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study. (7th April 2020)

• Record Type: Journal Article
• Authors: Tsugu, Toshimitsu; Postolache, Adriana; Dulgheru, Raluca; Sugimoto, Tadafumi; Tridetti, Julien; Nguyen Trung, Mai-Linh; Piette, Caroline; Moonen, Marie; Manganaro, Roberta; Ilardi, Federica; Chitroceanu, Alexandra Maria; Sperlongano, Simona; Go, Yun Yun; Kacharava, George; Athanassopoulos, George D; Barone, Daniele; Baroni, Monica; Cardim, Nuno; Hagendorff, Andreas; Hristova, Krasimira; Lopez, Teresa; de la Morena, Gonzalo; Popescu, Bogdan A; Penicka, Martin; Ozyigit, Tolga; Rodrigo Carbonero, Jose David; van de Veire, Nico; Von Bardeleben, Ralph Stephan; Vinereanu, Dragos; Zamorano, Jose Luis; Rosca, Monica; Calin, Andreea; Magne, Julien; Cosyns, Bernard; Galli, Elena; Donal, Erwan; Santoro, Ciro; Galderisi, Maurizio; Badano, Luigi P; Lang, Roberto M; Lancellotti, Patrizio;
• Is Part Of: European heart journal. Volume 21:Number 8(2020)
• Page Start: 896
• Page End: 905
• Publication Date: 2020-04-07
• Subjects: adult echocardiography -- 2D echocardiography -- deformation imaging -- reference values; Cardiovascular system -- Imaging -- Periodicals; Heart -- Imaging -- Periodicals; 616.10754
• DOI: 10.1093/ehjci/jeaa050
• Languages: English
• ISSNs: 2047-2404

Abstract

Abstract: Aims : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results : A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were −15.0% in men and −15.6% in women for epicardial strain, −16.8% and −17.7% for mid-myocardial strain, and −18.7% and −19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = −0.20, P = 0.007, mid-myocardial; r = −0.21, P = 0.006, endocardial; r = −0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1). Conclusion : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.