Balloon pulmonary angioplasty improves right atrial reservoir and conduit functions in chronic thromboembolic pulmonary hypertension. (1st May 2020)

• Record Type: Journal Article
• Authors: Yamasaki, Yuzo; Abe, Kohtaro; Kamitani, Takeshi; Hosokawa, Kazuya; Kawakubo, Masateru; Sagiyama, Koji; Hida, Tomoyuki; Matsuura, Yuko; Murayama, Yuriko; Funatsu, Ryohei; Tsutsui, Hiroyuki; Yabuuchi, Hidetake
• Is Part Of: European heart journal. Volume 21:Number 8(2020)
• Page Start: 855
• Page End: 862
• Publication Date: 2020-05-01
• Subjects: right atrial function -- chronic thromboembolic pulmonary hypertension -- balloon pulmonary angioplasty -- cardiac magnetic resonance imaging; Cardiovascular system -- Imaging -- Periodicals; Heart -- Imaging -- Periodicals; 616.10754
• DOI: 10.1093/ehjci/jeaa064
• Languages: English
• ISSNs: 2047-2404

Abstract

Abstract: Aims: Right atrial (RA) function largely contributes to the maintenance of right ventricular (RV) function. This study investigated the effect of balloon pulmonary angioplasty (BPA) on RA functions in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) using cardiac magnetic resonance imaging (CMRI). Methods and results: CMRI and RV catheterization were performed before BPA sessions and at the follow-up periods in 29 CTEPH patients. Reservoir [RA longitudinal strain (RA-LS)], passive conduit [RA early LS rate (LSR)], and active (RA late LSR) phases were assessed by using cine CMRI and a feature-tracking algorithm. The relationships between the changes in RA functions and in brain natriuretic peptide (BNP) were evaluated in both the dilated and non-dilated RA groups. RA-LS (32.4% vs. 42.7%), RA LSR (6.3% vs. 8.3%), and RA early LSR (−2.3% vs. −4.3%) were improved after BPA, whereas no significant change was seen in RA late LSR. The changes in RA peak LS and in RA early LSR were significantly correlated with the changes in BNP (ΔRA-LS: r = −0.63, ΔRA-early LSR: r = 0.65) and pulmonary vascular resistance (PVR) (ΔRA-LS: r = −0.69, ΔRA-early LSR: r = 0.66) in the nondilated RA group. Conclusion: The RA reservoir and passive conduit functions were impaired in inoperable CTEPH, whereas RA active function was preserved. BPA markedly reversed these impaired functions. The improvements in RA reservoir and conduit functions were significantly correlated with the changes in BNP levels and PVR in CTEPH patients with normal RA sizes.