Autophagy mechanisms and roles: recent advances and implications. (22nd October 2020)

• Record Type: Journal Article
• Authors: Markaki, Maria; Tavernarakis, Nektarios
• Is Part Of: FEBS journal. Volume 287:Number 23(2020)
• Page Start: 5024
• Page End: 5026
• Publication Date: 2020-10-22
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.15573
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Autophagy is the main catabolic process by which cells recycle cytoplasmic components and superfluous or damaged organelles to preserve metabolic homeostasis under normal conditions and promote survival under stress. As a tightly regulated and dynamic process, autophagy has critical roles in development and cell differentiation, immune function, organismal health and lifespan. Accumulating findings suggest that defective or dysregulated autophagy accelerates ageing and increases susceptibility to diseases, such as neurodegenerative disorders and cancer, among others. This virtual issue of the FEBS Journal on Autophagy includes a collection of articles that present recent advances on the regulation of autophagy and provide a view of its complex roles in physiological and pathological contexts. Abstract : This Virtual Issue on Autophagy comprises nine reviews and two original research articles on the roles and molecular mechanisms of autophagy in physiological and pathological context recently published in the journal. The specific contributions of these articles are highlighted in the accompanying editorial by Maria Markaki and FEBS Journal editorial board member Nektarios Tavernarakis (photo).